Treatment is symptomatic. A specific antidote is not known. With symptoms of acute overdose it is recommended to induce vomiting or stomach wash. It is necessary to drink plenty of liquids and dynamic observation. With buy testosterone enanthatehemodialysis 20-30% of the dose is displayed gemifloxacin from plasma.
Allergic reactions: sometimes itching, hives; Hypersensitivity reactions: in some cases – Stevens-Johnson syndrome (malignant exudative erythema), toxic epidermal necrolysis (Lyell’s syndrome); very rarely increased photosensitivity, hypersensitivity pneumonitis. From the digestive system: nausea, diarrhea; sometimes vomiting, abdominal pain, flatulence, anorexia; rarely acute liver failure, hepatitis.From the nervous system: very rarely tremor, restlessness, anxiety, confusion, hallucinations, paranoid syndrome, depression, drowsiness. When symptoms stop receiving gemifloxacin. In some cases: sensory or sensorimotor axonal polyneuropathy, which manifests itself paresthesias, gipostezii and other violations of sensitivity, weakness. From the sensory organs: rarely disorders of taste and smell, visual disturbances (diplopia, changes in color vision), tinnitus, vertigo, hearing loss . From the hematopoietic system: leukopenia; rarely thrombocytopenia; very rare pancytopenia, thrombocytopenic purpura, agranulocytosis and / or other hematologic abnormalities; in some cases – anemia, including hemolytic and aplastic. From the urinary system: rarely crystalluria; in some cases – interstitial nephritis, acute renal failure. From the laboratory parameters: rarely – increasing the sodium content, decreased potassium concentration, increased total bilirubin, decrease in calcium concentration, increase in the number of platelets, decreased number of blood neutrophils, a change in hematocrit, increased activity of “liver “transaminases, increased creatine phosphokinase concentrations. On the part of the musculoskeletal system: very rarely arthralgia, arthritis, tenosynovitis, myalgia, tendon ruptures shoulder, hand, Achilles tendon and other tendons. others: vasculitis, superinfection (candidiasis, pseudomembranous colitis).
Interaction with other drugs
Antacids: gemifloxacin bioavailability is reduced buy testosterone enanthate when assigning antacids containing aluminum, magnesium or iron sulfate. Antacids should be taken at least 3 hours before or no sooner than 2 hours after taking gemifloxacin.
Sucralfate reduces the bioavailability of gemifloxacin. Sucralfate should be taken no earlier than 2 hours after taking gemifloxacin.
Oral contraceptives: estrogen-progesterone contraceptives slightly reduces the bioavailability of gemifloxacin. Course admission gemifloxacin did not affect the pharmacokinetics buy testosterone enanthate of ethinylestradiol / levonorgestrel contraceptives.
Acceptance of gemifloxacin to healthy volunteers, at the same time receiving probenecid, increased the (Area Under Curve – the area under “concentration-time” curve) on average by 45% and reduced the average renal clearance of gemifloxacin about 50%. The impact in the population at this level was not associated with an increase in frequency of adverse events.
Facts do not have a significant effect on the anticoagulant effect of heparin in healthy subjects receiving stable therapy with heparin. When using quinolones, including facts, in conjunction with warfarin or its derivatives mentioned episodes increase (international normalized ratio), (prothrombin time), or the development of clinical bleeding episodes.
Pregnancy and lactation
Facts should not be used in pregnant women, since safety in pregnancy has not been established. If necessary, use during lactation should stop breastfeeding
Effects on ability to drive and operate machinery.
Be careful when driving and busy with other potentially buy testosterone enanthate hazardous activities that require high concentration and psychomotor speed reactions, especially with simultaneous use of ethanol.